Male germ line transgenesis and siRNA technology for manipulating genes in domestic species

雄性种系转基因和操纵家养物种基因的 siRNA 技术

• 批准号: LX0560258
• 负责人: Prof Richard Ivell
• 金额: $ 10.29万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Linkage - International
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-08-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LX0560258
• 关键词: Male; germ; line; transgenesis; siRNA

Professor Shemesh has successfully developed male germ line transgenesis in species such as bovine and chicken. This technology allows genes to be manipulated via sperm in a wide range of animals besides mice, avoiding the need for a female in vitro fertilization regimen. He is curently applying interference RNA (siRNA) transgenically to manipulate genes in vivo. Together these two technologies offer immense possibilities to manipulate a wide range of species for economic, biotechnological or medical research purposes. Professor Shemesh wishes to come to Adelaide to establish these technologies there as parts of ongoing research projects, related to the physiology of the ovarian hormone relaxin in aging research.

Shemesh教授已经成功地在牛和鸡等物种中开发了雄性生殖系转基因。这项技术允许通过小鼠以外的各种动物的精子操纵基因，避免了对女性体外受精方案的需要。他目前正在应用干扰RNA（siRNA）转基因技术在体内操纵基因。这两种技术结合起来，为经济、生物技术或医学研究目的操纵各种物种提供了巨大的可能性。Shemesh教授希望来到阿德莱德，在那里建立这些技术，作为正在进行的研究项目的一部分，与衰老研究中卵巢激素松弛素的生理学有关。