Establishment of the endocrine axes in the embryo and their xenobiotic distortion

胚胎中内分泌轴的建立及其外源性扭曲

• 批准号: DP0773315
• 负责人: Prof Richard Ivell
• 金额: $ 22.64万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0773315
• 关键词: Establishment; endocrine; axes; embryo; their

Millions of tons of supposedly harmless chemicals are produced and enter the environment each year. However, some of these substances can act on wildlife and humans to distort the way that hormone systems are established in the embryo, leading to subtle effects on health and function in later life. We will use one of the commonest of these substances, found in many cosmetics, food wrappings, and medicinal plastics, to learn how hormone systems becomes established in a healthy embryo, and how these then get distorted after exposure to these compounds. This project directly addresses the way we assess the health of our environment, and offers ways to screen for compounds which can have subtle effects on wildlife, domestic species and humans.

每年有数百万吨本应无害的化学品被生产出来并进入环境。然而，其中一些物质可以作用于野生动物和人类，扭曲激素系统在胚胎中建立的方式，从而对晚年的健康和功能产生微妙的影响。我们将使用这些物质中最常见的一种，在许多化妆品，食品包装和药用塑料中发现，以了解激素系统如何在健康的胚胎中建立，以及在暴露于这些化合物后如何扭曲。该项目直接解决了我们评估环境健康的方式，并提供了筛选可能对野生动物、家养物种和人类产生微妙影响的化合物的方法。