Diabetes and the mechanism(s) of renal tubular apoptosis in db/db mouse kidneys

糖尿病和 db/db 小鼠肾脏肾小管凋亡的机制

• 批准号: 202359
• 负责人: Chan John S
• 金额: $ 44.19万
• 依托单位: Centre hospitalier de l'Universit de Montral (CHUM)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-03-01 至 2015-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=202359&lang=en
• 关键词: Albumin; Angiotensinogen; Caspase-12 Gene Expression; Diabetic Nephropathy; Molecular And Cell Biology; Oxidative Stress; Renal Proximal Tubular Cells; Renin-Angiotensin System; Transgenic Mice; Tubular Apoptosis And Atrophy

Diabetic nephropathy (DN) is a major cause of morbidity and mortality in both type 1 and type 2 diabetics. It is estimated that approximately 30-50% of diabetic patients in Canada and in the USA will eventually develop chronic renal failure (or end-stage

糖尿病肾病（DN）是1型和2型糖尿病患者发病和死亡的主要原因。据估计，在加拿大和美国，大约30-50%的糖尿病患者最终将发展为慢性肾衰竭（或终末期肾病）。