Probing the circuits responsible for stroke recovery with light-mediated circuit monitoring and manipulation in mouse models.

在小鼠模型中通过光介导的回路监测和操作来探测负责中风恢复的回路。

• 批准号: 210064
• 负责人: Murphy Timothy H
• 金额: $ 69.01万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-09-01 至 2015-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=210064&lang=en
• 关键词: 2-Photon Imaging; Calcium; Channelrhodopsin-2; Dendrite; Optogenetics; Plasticity; Stroke; Synapse

Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which results in damage to neuronal networks and impairment of sensation, movement, or cognition. Although stroke damage can be devastating, many patients survive the

足够持续时间和程度的脑血流量减少导致中风，这导致神经元网络的损伤和感觉、运动或认知的损害。虽然中风的损害可能是毁灭性的，但许多患者都能存活下来。