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Functional interactions between PI3K-Akt and eIF2alpha phosphorylation pathways: Implications in cell signaling and tumor treatment.

Functional interactions between PI3K-Akt and eIF2alpha phosphorylation pathways: Implications in cell signaling and tumor treatment.
PI3K-Akt 和 eIF2α 磷酸化途径之间的功能相互作用：对细胞信号传导和肿瘤治疗的影响。
批准号：
212223
负责人：
Koromilas Antonis E
金额：
$48.0万
依托单位：
Lady Davis Institute for Medical Research (Mtl)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2010
资助国家：
加拿大
项目状态：
已结题
起止时间：
2010-09-01 至 2015-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=212223&lang=en
关键词：
Apoptosis Chemotherapeutic Drugs Eif2alpha Phosphorylation Endoplasmic Reticulum Stress Mrna Translation Oxidative Stress Pi3k-Akt Pathway Protein Phosphorylation Tumorigenesis Xenograft Tumor Assays

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Synthesis of proteins within cells is a complicated process, which is affected by signals that the cells receive from their environment. Deregulation of the machinery that synthesizes proteins is often associated with uncontrolled cell proliferation, indu
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