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Mechanisms and therapeutic implications of PKR and eIF2 phosphorylation in HER2 breast tumor suppression.

Mechanisms and therapeutic implications of PKR and eIF2 phosphorylation in HER2 breast tumor suppression.
PKR 和 eIF2 磷酸化在 HER2 乳腺肿瘤抑制中的机制和治疗意义。
批准号：
366638
负责人：
Koromilas Antonis E
金额：
$7.29万
依托单位：
Lady Davis Institute for Medical Research (Mtl)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2016
资助国家：
加拿大
项目状态：
已结题
起止时间：
2016-11-01 至 2017-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=366638&lang=en
关键词：
Breast Cancer Chemotherapies Eif2 Erk Her2 Mrna Translation Notch Pkr Transgenic Mice Trastuzumab

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中文摘要
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英文摘要
HER2+ breast tumors are highly invasive and metastatic. Specific drugs for HER2+ breast cancers, called Trastuzumab (Herceptin) and Lapatinib (Tykerb), are used to substantially increase the chance of patient survival in single or combined treatments with
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Deciphering the metabolic and tumorigenic functions of STAT1 in mutant KRAS cancer.
eIF2 phosphatase inhibitors in the treatment of Trastuzumab-resistant breast cancer.
The implication of the adaptive arm of the integrated stress response in KRAS lung cancer.
The function of eIF2alpha phosphorylation in Ras signaling and lung tumorigenesis.
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