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Mechanism of conformationally defective membrane proteins removal from the cell surface in health and diseases

Mechanism of conformationally defective membrane proteins removal from the cell surface in health and diseases
健康和疾病中构象缺陷膜蛋白从细胞表面去除的机制
批准号：
212493
负责人：
Lukacs Gergely L
金额：
$51.67万
依托单位：
McGill University
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2010
资助国家：
加拿大
项目状态：
已结题
起止时间：
2010-09-01 至 2015-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=212493&lang=en
关键词：
Conformational Disease Endocytosis Protein Processing Proteolysis Quality Control Ubiquitination

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英文摘要
To preserve cellular homeostasis, proteins with impaired architecture have to be repaired or eliminated from living cells in a timely manner. Since structural errors are frequently incorporated in newly synthesized proteins, as well as imposed by various
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