Molecular basis and correction of CFTR defects in respiratory epithelial cells

呼吸道上皮细胞CFTR缺陷的分子基础及纠正

• 批准号: 323359
• 负责人: Lukacs Gergely L
• 金额: $ 52.26万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-03-01 至 2020-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=323359&lang=en
• 关键词: Cftr; Cystic Fibrosis; Cytokine; Degradation; Innate Immunity; Membraen Traffic; Misfolding; Phenotypic Screen; Ubiquitination

The cystic fibrosis (CF) protein (CFTR) resides at the cell surface and ensures normal water and ion content of the liquid that lines the airway surface. The most common mutation in cystic fibrosis impairs the structure and function of CFTR and alters the

囊性纤维化（CF）蛋白（CFTR）位于细胞表面，并确保气道表面液体的正常水和离子含量。囊性纤维化中最常见的突变会损害CFTR的结构和功能并改变CFTR的结构和功能。