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Molecular basis and modulation of CFTR trafficking defect in respiratory epithelial cells

Molecular basis and modulation of CFTR trafficking defect in respiratory epithelial cells
呼吸道上皮细胞 CFTR 运输缺陷的分子基础和调节
批准号:
313966
负责人:
Lukacs Gergely L
金额:
$7.29万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2014
资助国家:
加拿大
项目状态:
已结题
起止时间:
2014-05-01 至 2015-05-01

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中文摘要
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英文摘要
The cystic fibrosis protein (CFTR) resides at the cell surface and ensures normal water and ion content of the airway surface liquid. Mutations and chronic lung diseases can impair CFTR accumulation and function at the plasma membrane and consequentially
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Mechanism and pharmacological modulation of intrinsic and acquired pro-inflammatory state of the airway epithelia in cystic fibrosis
  • 批准号:
    445259
  • 项目类别:
    Operating Grants
  • 资助金额:
    $61.3万
  • 财政年份:
    2021
  • 负责人:
    Lukacs Gergely L
  • 依托单位:
Molecular basis of and preclinical approaches to overcome therapy-resistant cystic fibrosis mutations
  • 批准号:
    420116
  • 项目类别:
    Operating Grants
  • 资助金额:
    $66.32万
  • 财政年份:
    2020
  • 负责人:
    Lukacs Gergely L
  • 依托单位:
Rational optimization of CFTR modulators and assessment of predictive potential of novel cystic fibrosis (CF) airway epithelial models for clinical outcome
  • 批准号:
    358504
  • 项目类别:
    Operating Grants
  • 资助金额:
    $54.89万
  • 财政年份:
    2016
  • 负责人:
    Lukacs Gergely L
  • 依托单位:
Molecular basis and correction of CFTR defects in respiratory epithelial cells
  • 批准号:
    323359
  • 项目类别:
    Operating Grants
  • 资助金额:
    $52.26万
  • 财政年份:
    2015
  • 负责人:
    Lukacs Gergely L
  • 依托单位:
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