Disrupting Chemical Communication in Bacteria: A Novel and Effective Antimicrobial Strategy

破坏细菌中的化学通讯：一种新颖有效的抗菌策略

• 批准号: DP1095159
• 负责人: Prof Naresh Kumar
• 金额: $ 22.26万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1095159
• 关键词: Disrupting; Chemical; Communication; Bacteria; Novel

Due to increased application of antibiotics for disease control, many pathogenic bacteria have developed resistance to existing antimicrobials. The infections associated with the resistant bacteria incur a high cost in terms of human health, well being and health care costs. Thus, there is a clear need to develop new antimicrobials that have a novel mechanism of action. The technology proposed here has the potential to deliver enormous health and social welfare benefits to the Australian population as well as commercial benefits to Australian industry, through provision of new, locally produced technologies for the control of bacterial virulence.

由于抗生素在疾病控制中的应用增加，许多病原菌对现有的抗菌剂产生了耐药性。 与耐药细菌相关的感染在人类健康、福祉和医疗保健成本方面带来了高成本。因此，显然需要开发具有新的作用机制的新的抗菌剂。 这里提出的技术有可能提供巨大的健康和社会福利的好处，澳大利亚人口以及澳大利亚工业的商业利益，通过提供新的，当地生产的技术，控制细菌的毒性。