Novel peptide mimics for the disruption of chemical communication in bacteria

现在已经确定，细菌之间通过可扩散的小信号分子相互通信，并以协调的方式协调它们的活动，如生物膜的形成、聚集和毒力因子的表达。这个项目将研究新型有机分子的合成，这些分子能够扰乱细菌中的化学交流。这可以在不使用抗生素、防腐剂和消毒剂等生长抑制剂的情况下控制不需要的微生物活动，这些药物是为耐药微生物选择的。这种根除微生物毒力行为的优雅方法代表了一种抗击抗菌素耐药性的新战略。

It is now well established that bacteria communicate with each other via small diffusible signalling molecules and coordinate their activities such as biofilm formation, swarming and expression of virulence factors in a coordinated manner. This project will investigate the synthesis of novel organic molecules that have the capacity to disrupt chemical communication in bacteria. This could allow control of the unwanted microbial activity without the use of growth inhibitory agents such as antibiotics, preservatives and disinfectants that select for the resistant organisms. This elegant approach to eradicating the virulence behaviour of microbes represents a novel strategy to combat antimicrobial resistance.