Development of a live vaccine for gut health in poultry

开发促进家禽肠道健康的活疫苗

• 批准号: LP160101044
• 负责人: Prof Robert Moore
• 金额: $ 31.28万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-12-15 至 2022-02-12
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP160101044
• 关键词: Development; live; vaccine; gut; health

Development of a live vaccine for gut health in poultry. The project aims to develop a live vaccine against necrotic enteritis, a disease of poultry estimated to cost the global poultry industry $5-6 billion USD/annum. It builds on work that has demonstrated the efficacy of an experimental vaccine. The proven antigen, NetB, will be expressed in live delivery vehicles, including the apicomplexan parasite Eimeria and several bacteria strains particularly suited to use in chickens. Comparative analysis of the different vaccine vehicles will allow evaluation of the relative advantages and disadvantage of the different vehicles for delivery of heterologous vaccine antigens, thus informing the choice of appropriate vectors for this and other vaccine applications.

家禽肠道健康活疫苗的研制。该项目旨在开发针对坏死性肠炎的活疫苗，这是一种家禽疾病，估计每年给全球家禽业造成50 - 60亿美元的损失。它建立在已经证明实验疫苗有效性的工作基础上。经证实的抗原NetB将在活的递送载体中表达，包括顶复形寄生虫艾美球虫和几种特别适合用于鸡的细菌菌株。不同疫苗载体的比较分析将允许评价用于递送异源疫苗抗原的不同载体的相对优点和缺点，从而告知用于该疫苗应用和其它疫苗应用的适当载体的选择。