Development of a live vaccine for gut health in poultry

家禽肠道健康活疫苗的研制。该项目旨在开发一种针对坏死性肠炎的活疫苗。坏死性肠炎是一种家禽疾病，估计每年给全球家禽业造成50-60亿美元的损失。它建立在已经证明了实验性疫苗有效性的工作基础上。已证实的抗原NetB将在活体递送工具中表达，包括顶端复合体寄生虫艾美耳球虫和几种特别适合于鸡使用的细菌菌株。对不同疫苗载体的比较分析将能够评估不同载体输送异种疫苗抗原的相对优势和劣势，从而为这种疫苗和其他疫苗应用选择合适的载体。

Development of a live vaccine for gut health in poultry. The project aims to develop a live vaccine against necrotic enteritis, a disease of poultry estimated to cost the global poultry industry $5-6 billion USD/annum. It builds on work that has demonstrated the efficacy of an experimental vaccine. The proven antigen, NetB, will be expressed in live delivery vehicles, including the apicomplexan parasite Eimeria and several bacteria strains particularly suited to use in chickens. Comparative analysis of the different vaccine vehicles will allow evaluation of the relative advantages and disadvantage of the different vehicles for delivery of heterologous vaccine antigens, thus informing the choice of appropriate vectors for this and other vaccine applications.