New insights into mammalian gene transcription - the role of parafibromin

随着我们进入有针对性的分子疗法来治疗疾病的时代，增加我们对基本基因和蛋白质相互作用的知识是当务之急。癌症处于这些疾病的前沿，希望改进治疗方法，牢牢建立在对肿瘤基本细胞生物学的了解基础上。这项提案描述了对一种名为副纤维蛋白的蛋白质的研究。我们认为，副纤维蛋白通过调节参与细胞应激反应的蛋白质水平，在负责细胞如何管理应激的主要途径中发挥作用。在这项研究过程中的发现将提供关于基因和蛋白质相互作用的知识，这对未来开发抗癌疗法将是重要的。

Increasing our knowledge of fundamental gene and protein interactions is imperative as we move into an era of targetted molecular therapies to treat disease. Cancer is at the forefront of these diseases with hope of improved treatments firmly based in understanding the basic cell biology of tumours. This proposal describes research into a protein called parafibromin. We propose that parafibromin acts in major pathways responsible for how a cell manages stress by regulating levels of proteins involved in the cellular stress response. Discoveries made during the course of this research will provide knowledge of gene and protein interactions that will be important in the future to develop anti-cancer therapies.