New insights into mammalian gene transcription - the role of parafibromin

对哺乳动物基因转录的新见解——副纤维蛋白的作用

• 批准号: DP1093195
• 负责人: Prof Deborah Marsh
• 金额: $ 24.03万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-06-03 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1093195
• 关键词: New; insights; into; mammalian; gene

Increasing our knowledge of fundamental gene and protein interactions is imperative as we move into an era of targetted molecular therapies to treat disease. Cancer is at the forefront of these diseases with hope of improved treatments firmly based in understanding the basic cell biology of tumours. This proposal describes research into a protein called parafibromin. We propose that parafibromin acts in major pathways responsible for how a cell manages stress by regulating levels of proteins involved in the cellular stress response. Discoveries made during the course of this research will provide knowledge of gene and protein interactions that will be important in the future to develop anti-cancer therapies.

随着我们进入靶向分子疗法治疗疾病的时代，增加我们对基本基因和蛋白质相互作用的了解势在必行。癌症处于这些疾病的最前沿，希望在了解肿瘤基本细胞生物学的基础上改进治疗方法。该提案描述了对一种称为parafibromin的蛋白质的研究。我们认为，副纤维蛋白通过调节参与细胞应激反应的蛋白质水平，在负责细胞如何管理应激的主要途径中发挥作用。这项研究过程中的发现将提供基因和蛋白质相互作用的知识，这对未来开发抗癌疗法至关重要。