Pyk2: a central mediator of gonadotropin action in ovarian cancer

卵巢癌通常出现在晚期，5年生存率低于25%。绝经后特定激素水平的升高可能会增加患这种癌症的风险。我们已经证明，一种名为Pyk2的蛋白质在这些激素的作用下被激活，并可能在卵巢癌细胞的迁移、侵袭和增殖中发挥重要作用。该项目将研究这种蛋白的作用，目的是改善卵巢癌妇女的治疗方法。

Ovarian cancer generally presents at an advanced stage where 5 yr survival is less than 25%. Elevated levels of specific hormones after menopause may increase the risk of this cancer. We have shown that a protein called Pyk2 is activated in response to these hormones and may have significant roles in ovarian cancer cell migration, invasion and proliferation. This project will investigate the role of this protein, with the goal of improved therapeutics for women with ovarian cancer.