Pyk2: a central mediator of gonadotropin action in ovarian cancer

Pyk2：卵巢癌中促性腺激素作用的中心介质

• 批准号: nhmrc : 1005715
• 负责人: Prof Deborah Marsh
• 金额: $ 22.27万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pyk2-central-mediator-ovarian-cancer/109106
• 关键词: Pyk2; central; mediator; gonadotropin; action

Ovarian cancer generally presents at an advanced stage where 5 yr survival is less than 25%. Elevated levels of specific hormones after menopause may increase the risk of this cancer. We have shown that a protein called Pyk2 is activated in response to these hormones and may have significant roles in ovarian cancer cell migration, invasion and proliferation. This project will investigate the role of this protein, with the goal of improved therapeutics for women with ovarian cancer.

卵巢癌通常出现在晚期，5年生存率低于25%。绝经后特定激素水平升高可能会增加患这种癌症的风险。我们已经表明，一种名为Pyk2的蛋白质在对这些激素的反应中被激活，并且可能在卵巢癌细胞迁移，侵袭和增殖中起重要作用。该项目将研究这种蛋白质的作用，目的是改善卵巢癌妇女的治疗方法。