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Modeling the Functional Impact of Genetic Variants Associated with Doxorubicin-Induced Cardiotoxicity in Genome-edited Isogenic Human Cells

Modeling the Functional Impact of Genetic Variants Associated with Doxorubicin-Induced Cardiotoxicity in Genome-edited Isogenic Human Cells
在基因组编辑的同基因人类细胞中模拟与阿霉素诱导的心脏毒性相关的遗传变异的功能影响
批准号:
329881
负责人:
Brunham Liam R
金额:
$7.29万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-03-01 至 2016-03-01

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英文摘要
Forty percent of Canadians will develop cancer in their lifetime. Doxorubicin is a one of the most commonly used and effective drugs to treat cancer, but it can cause heart damage in up to one-quarter of patients who receive it. We currently lack ways to
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CETP Inhibition as a novel treatment to remove pathogen lipids and improve survival in sepsis
  • 批准号:
    407923
  • 项目类别:
    Operating Grants
  • 资助金额:
    $44.58万
  • 财政年份:
    2019
  • 负责人:
    Brunham Liam R
  • 依托单位:
Improving the identification and treatment of young adults with heart disease: the Study to Avoid cardioVascular Events in British Columbia (SAVE BC)
  • 批准号:
    389181
  • 项目类别:
    Operating Grants
  • 资助金额:
    $47.65万
  • 财政年份:
    2018
  • 负责人:
    Brunham Liam R
  • 依托单位:
Canada Research Chair - Tier 2 - CIHR Funded
  • 批准号:
    384895
  • 项目类别:
  • 资助金额:
    $36.43万
  • 财政年份:
    2017
  • 负责人:
    Brunham Liam R
  • 依托单位:
Investigating Pharmacogenetic Mechanisms of Doxorubicin-Induced Cardiotoxicty in Human Pluripotent Stem Cell-Derived Cardiomyocytes
  • 批准号:
    358484
  • 项目类别:
    Operating Grants
  • 资助金额:
    $42.35万
  • 财政年份:
    2016
  • 负责人:
    Brunham Liam R
  • 依托单位:
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