Investigating Pharmacogenetic Mechanisms of Doxorubicin-Induced Cardiotoxicty in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Investigating Pharmacogenetic Mechanisms of Doxorubicin-Induced Cardiotoxicty in Human Pluripotent Stem Cell-Derived Cardiomyocytes
研究人多能干细胞来源的心肌细胞中阿霉素诱导的心脏毒性的药物遗传学机制
批准号：
358484
负责人：
Brunham Liam R
金额：
$42.35万
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2016
资助国家：
加拿大
项目状态：
已结题
起止时间：
2016-10-01 至 2021-10-01
中文摘要
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英文摘要
Many anti-cancer drugs cause side effects that damage the heart. Doxorubicin is one of the most commonly used anti-cancer drugs and is used to treat breast cancer, lymphoma, and many childhood cancers. However, up to 26% of patients who receive this drug
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Modeling the Functional Impact of Genetic Variants Associated with Doxorubicin-Induced Cardiotoxicity in Genome-edited Isogenic Human Cells
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项目类别：Operating Grants
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负责人：Brunham Liam R
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依托单位：
海外基金
