AhR-dependent alterations in the intestinal permeability of C57BL/6 mice following repeated TCDD exposure

反复接触 TCDD 后 C57BL/6 小鼠肠道通透性发生 AhR 依赖性变化

• 批准号: 327844
• 负责人: Fader Kelly A
• 金额: $ 7.65万
• 依托单位: Michigan State University (E. Lansing)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-10-01 至 2017-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=327844&lang=en
• 关键词: Aryl Hydrocarbon Receptor (Ahr); Bioinformatics; Digestive System; Dioxin; Metabolic Disorders; Non-Alcoholic Fatty Liver Disease (Nafld); Rna-Sequencing; Sex-Specificity; Toxicology; Ussing Chambers

Approximately 1 in 5 Canadian adults suffer from obesity, elevated blood lipids, high blood pressure and high blood sugar, commonly referred to as Metabolic Syndrome (MetS). In the liver, MetS is first observed as fat accumulation which can develop into n

大约五分之一的加拿大成年人患有肥胖，血脂升高，高血压和高血糖，通常被称为代谢综合征（MetS）。在肝脏中，MetS首先被观察到为脂肪积累，其可发展成代谢产物。