Latent inhibition: Behavioural characteristics and neural substrates

潜在抑制：行为特征和神经基质

• 批准号: DP1096570
• 负责人: Prof Reginald Westbrook
• 金额: $ 20.84万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1096570
• 关键词: Latent; inhibition; Behavioural; characteristics; neural

Latent inhibition is an animal model of schizophrenia. It refers to the impairment in learned performance when a pre-exposed stimulus signals something of importance. The initial learning interferes with the subsequent learning. This effect fails to occur in schizophrenics but occurs after their treatment with antipsychotic medication. The project will provide the basis for a comprehensive theory of the processes involved in the effect and their neural substrates. Such a theory will clarify the processes and neural substrates disrupted in schizophrenia. Students will receive training in behavioural neuroscience, and publication of results in journals and presentations at conferences will add to the reputation of Australian science.

潜伏抑制是精神分裂症的动物模型。它指的是当预先暴露的刺激发出重要信号时，学习表现的损害。最初的学习会影响后来的学习。这种效应在精神分裂症患者中不会发生，但在他们接受抗精神病药物治疗后会发生。该项目将提供一个全面的理论基础的过程中所涉及的影响和他们的神经基板。这样的理论将阐明精神分裂症中被破坏的过程和神经基质。学生将接受行为神经科学方面的培训，并在期刊上发表成果和在会议上发表演讲，这将增加澳大利亚科学的声誉。