How an innocuous event never associated with danger becomes frightening

一个与危险无关的无害事件如何变得令人恐惧

• 批准号: DP190100747
• 负责人: Prof Reginald Westbrook
• 金额: $ 23.42万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190100747
• 关键词: How; innocuous; event; never; associated

This project aims to investigate how the components of a fear memory are consolidated in specific regions of the medial temporal lobe using an animal model. The project intends to identify how the distinct components are integrated such that cues never before associated with danger become frightening. This knowledge is expected to improve understanding of basic memory processes and the failures of memory that characterise fear-related disorders. Intended benefits include improved strategies for the management of fear in disorders like post-traumatic stress, and development of new theories regarding the way in which animals generate expectations about absent events.

本项目旨在通过动物模型研究恐惧记忆的组成部分是如何在内侧颞叶的特定区域中巩固的。该项目旨在确定不同的组成部分是如何整合的，使得以前从未与危险联系在一起的线索变得令人恐惧。这些知识有望提高对基本记忆过程和记忆失败的理解，从而避免与恐惧相关的疾病。预期的好处包括改善创伤后应激障碍等疾病的恐惧管理策略，以及发展关于动物对缺席事件产生期望的新理论。