The role of context in the acquisition, extinction and reinstatement of fear

情境在恐惧的获得、消除和恢复中的作用

• 批准号: ARC : DP0209523
• 负责人: Prof Reginald Westbrook
• 金额: $ 15万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/the-role-context-reinstatement-fear/67137
• 关键词: role; context; acquisition; extinction; reinstatement

The role of context in the acquisition, extinction and reinstatement of fear. Behavioural studies have identified a role for context in the development, extinction and reactivation of fear memories. Although there has been significant progress in delineating the neural pathways for fear conditioning, less is known about the substrates that represent the context of conditioning. This project studies the neural substrates of the processes by which context controls the acquisition, extinction and reactivation of fear memories. Specifically, it examines the role of information flow between the dorsal subiculum and the accumbens nucleus in the processes by which rats learn about environmental context and the control exerted by such contexts on fear memories.

背景在恐惧的获得、消除和恢复中的作用。行为研究已经确定了恐惧记忆的发展、消失和重新激活中的背景作用。虽然在描绘恐惧条件反射的神经通路方面取得了重大进展，但对代表条件反射背景的底物知之甚少。本项目研究的是情境控制恐惧记忆获得、消退和再激活过程的神经基质。具体而言，它检查的作用，背下托和延髓核之间的信息流的过程中，大鼠了解环境的背景和控制施加的恐惧记忆的背景。