The role of context in the acquisition, extinction and reinstatement of fear

语境在恐惧的获得、消退和恢复中的作用。行为研究已经确定了环境在恐惧记忆的发展、消退和重新激活中所起的作用。尽管在描绘恐惧条件作用的神经通路方面已经取得了重大进展，但对代表条件作用的底物知之甚少。这个项目研究环境控制恐惧记忆的获得、消退和重新激活的过程的神经基础。具体地说，它考察了背侧下托和伏隔核之间的信息流在大鼠学习环境背景的过程中的作用，以及这些环境对恐惧记忆的控制。

The role of context in the acquisition, extinction and reinstatement of fear. Behavioural studies have identified a role for context in the development, extinction and reactivation of fear memories. Although there has been significant progress in delineating the neural pathways for fear conditioning, less is known about the substrates that represent the context of conditioning. This project studies the neural substrates of the processes by which context controls the acquisition, extinction and reactivation of fear memories. Specifically, it examines the role of information flow between the dorsal subiculum and the accumbens nucleus in the processes by which rats learn about environmental context and the control exerted by such contexts on fear memories.