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Inhibiting lung cancer by targeting disulfide reductase enzymes with a novel small molecule that induces reactive oxygen species

Inhibiting lung cancer by targeting disulfide reductase enzymes with a novel small molecule that induces reactive oxygen species
通过用诱导活性氧的新型小分子靶向二硫键还原酶来抑制肺癌
批准号：
412153
负责人：
Johnson Fraser
金额：
$0.11万
依托单位：
B.C. Cancer Research Centre (Vancouver)
依托单位国家：
加拿大
项目类别：
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-09-01 至 2020-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=412153&lang=en
关键词：
Lung Cancer Oxidative Stress Proteomics Target Discovery Thermal Proteome Profiling

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中文摘要
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英文摘要
Lung cancer (LC) is the leading cause of cancer deaths worldwide, mainly due to the lack of effective drugs available. Most current therapies are focused on targeting genes mutated in lung cancer; however, tumours may require other, non-mutated genes for
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Identifying genetic factors that determine responsiveness to therapeutic HIF2a pathway inactivation in Birt-Hogg-Dubé syndrome-associated renal cell carcinoma
A novel mechanism of reactive oxygen species-induced synthetic lethality in lung cancer
The maternal embryonic leucine zipper kinase as a therapeutic target in castration-resistant prostate cancer
  • 批准号：
    367163
  • 项目类别：
    Studentship Programs
  • 资助金额：
    $1.27万
  • 财政年份：
    2016
  • 负责人：
    Johnson Fraser
  • 依托单位：
    University of British Columbia
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