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A novel mechanism of reactive oxygen species-induced synthetic lethality in lung cancer

A novel mechanism of reactive oxygen species-induced synthetic lethality in lung cancer
活性氧诱导肺癌合成致死的新机制
批准号：
404170
负责人：
Johnson Fraser
金额：
$7.65万
依托单位：
B.C. Cancer Research Centre (Vancouver)
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2018
资助国家：
加拿大
项目状态：
已结题
起止时间：
2018-10-01 至 2021-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=404170&lang=en
关键词：
Bioinformatics Cancer Biology Drug Characterization Lung Cancer Oxidative Stress Proteomics Target Discovery Thermal Proteome Profiling

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中文摘要
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英文摘要
Lung cancer is the leading cause of cancer death worldwide, mainly due to the lack of effective drugs available. This project studies a new way to inhibit lung cancer cells that focuses on exploiting cancer's inability to balance a chemical process called
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会议论文
Identifying genetic factors that determine responsiveness to therapeutic HIF2a pathway inactivation in Birt-Hogg-Dubé syndrome-associated renal cell carcinoma
Inhibiting lung cancer by targeting disulfide reductase enzymes with a novel small molecule that induces reactive oxygen species
The maternal embryonic leucine zipper kinase as a therapeutic target in castration-resistant prostate cancer
  • 批准号：
    367163
  • 项目类别：
    Studentship Programs
  • 资助金额：
    $1.27万
  • 财政年份：
    2016
  • 负责人：
    Johnson Fraser
  • 依托单位：
    University of British Columbia
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