Nanoimaging the cellular architecture of the malaria parasite, Plasmodium falciparum

疟原虫恶性疟原虫细胞结构的纳米成像

• 批准号: FS100100050
• 负责人: Prof Andrew Peele
• 金额: $ 19.3万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Super Science Fellowships
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-10-21 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FS100100050
• 关键词: Nanoimaging; cellular; architecture; malaria; parasite

The immediate benefit of this work will be in the understanding and treatment of malaria - a disease that kills approximately 1 million children annually. The ability to image the three-dimensional structure of cells at high resolution will allow us to ask fundamental questions about the cellular architecture of the malaria parasite and to design novel antimalarial strategies. By developing new methods for correlating structure and elemental location, the work in this proposal will offer a new paradigm for the study of cellular function and disease. This represents an important advance in the suite of investigative tools available to the biotechology sector and will see a corresponding improvement in our understanding of a wide range of disease states.

这项工作的直接好处将是了解和治疗疟疾-一种每年造成大约100万儿童死亡的疾病。以高分辨率成像细胞三维结构的能力将使我们能够提出有关疟疾寄生虫细胞结构的基本问题，并设计新的抗疟策略。通过开发将结构和元素位置相关联的新方法，该提案中的工作将为细胞功能和疾病的研究提供新的范式。这代表了生物技术部门可用的一套调查工具的重要进展，并将在我们对各种疾病状态的理解方面取得相应的改善。