The role of mechanosensing of tissue stiffness by dendritic cells and macrophages in promoting inflammation and obesity-associated insulin resistance

树突状细胞和巨噬细胞对组织硬度的机械传感在促进炎症和肥胖相关胰岛素抵抗中的作用

• 批准号: 449497
• 负责人: Lee Megan C
• 金额: $ 1.27万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2021-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=449497&lang=en
• 关键词: Dendritic Cells; Diabetes; Immunology; Insulin Resistance; Macrophages; Mechanosensing; Obesity; Tissue Stiffness

Obesity and associated insulin resistance (IR) predispose individuals to develop chronic metabolic diseases, such as type 2 diabetes and cardiovascular disease. These disorders affect a significant proportion of the global population, but their underlying

肥胖和相关的胰岛素抵抗（IR）使个体易患慢性代谢疾病，如2型糖尿病和心血管疾病。这些疾病影响了全球人口的很大一部分，但其潜在的