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The Role of Mitochondria and the NLRP3 Inflammasome in Right Ventricular Failure in Pulmonary Arterial Hypertension

The Role of Mitochondria and the NLRP3 Inflammasome in Right Ventricular Failure in Pulmonary Arterial Hypertension
线粒体和 NLRP3 炎性体在肺动脉高压右心室衰竭中的作用
批准号：
478986
负责人：
Archer Stephen L
金额：
$71.33万
依托单位：
Queen's University (Kingston, Ontario)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
未结题
起止时间：
2023-03-01 至 2028-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=478986&lang=en
关键词：
Biomarker Discovery Cardiomyocytes Damage-Associated Molecule Patterns Inflammation Macrophages Mitochondria Fission Pattern Recognition Receptors Polarization Right Ventricle Dysfunction Therapeutics

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中文摘要
翻译
右心室衰竭（RVF）是肺动脉高压（PAH）患者死亡的主要原因，目前的治疗方法并不针对右心室（RV）。肺动脉阻塞和收缩（肺动脉中的血管）
英文摘要
Right ventricular failure (RVF) is the leading cause of death in people with pulmonary arterial hypertension (PAH), and current therapies do not target the right ventricle (RV). Blockage and constriction of the pulmonary arteries (the blood vessels in the
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