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Molecular identification of the oxygen sensor(s) in the fetal ductus arteriosus and pulmonary artery: an integrated multiomic comparison of mitochondria in vital fetal arteries with opposing oxygen responses

Molecular identification of the oxygen sensor(s) in the fetal ductus arteriosus and pulmonary artery: an integrated multiomic comparison of mitochondria in vital fetal arteries with opposing oxygen responses
胎儿动脉导管和肺动脉中氧传感器的分子识别：对胎儿重要动脉中具有相反氧反应的线粒体进行综合多组学比较
批准号：
462691
负责人：
Archer Stephen L
金额：
$77.74万
依托单位：
Queen's University (Kingston, Ontario)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2022
资助国家：
加拿大
项目状态：
未结题
起止时间：
2022-03-01 至 2027-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=462691&lang=en
关键词：
Drug Therapeutics/Discovery Ductus Arteriosis Electron Transport Chain Hypoxia Mitochondria Normoxia Oxygen Sensing Proteomics Pulmonary Artery Transcriptomics

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Before birth, blood flow to fetal lungs is minimal and oxygen (O2) is provided by the placenta. The ductus arteriosus (DA), an artery connecting the pulmonary artery (PA) and aorta, allows blood from the right heart to bypass the unventilated lungs. With
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