Therapy-Related Hepatic Mitochondrial Toxicity in HepG2 Cells and in Patients Co-Infected with HIV and Hepatitis C Virus

HepG2 细胞以及同时感染 HIV 和丙型肝炎病毒的患者中与治疗相关的肝线粒体毒性

• 批准号: 195923
• 负责人: Wade Rachel E
• 金额: $ 4.81万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-10-01 至 2012-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=195923&lang=en
• 关键词: Autophagy; Cell Culture; Co-Infection; Hepatitis C Virus; Highly Active Antiretroviral Therapy (Haart); Hiv/Aids; Liver; Mitochondrial Toxicity; Mutations; Sequencing

HIV and hepatitis C virus (HCV) share common routes of infection so that individuals are often infected with both. In BC, a third of HIV patients are co-infected with HCV. Half of HIV-infected individuals die of liver disease and of those, over 90% are co

艾滋病毒和丙型肝炎病毒（HCV）有共同的感染途径，因此个体经常同时感染两种病毒。在不列颠哥伦比亚省，三分之一的艾滋病毒患者同时感染丙型肝炎病毒。一半的艾滋病毒感染者死于肝病，其中90%以上的人死亡