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Osteopontin promotes breast cancer recurrence by establishing an inflammatory and fibrotic tumour microenvironment mediated by pro-tumourigenic macrophages and cancer-associated fibroblasts

Osteopontin promotes breast cancer recurrence by establishing an inflammatory and fibrotic tumour microenvironment mediated by pro-tumourigenic macrophages and cancer-associated fibroblasts
骨桥蛋白通过建立由促肿瘤巨噬细胞和癌症相关成纤维细胞介导的炎症和纤维化肿瘤微环境来促进乳腺癌复发
批准号：
475794
负责人：
Gu Yu
金额：
$7.65万
依托单位：
McGill University
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2022
资助国家：
加拿大
项目状态：
未结题
起止时间：
2022-11-01 至 2025-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=475794&lang=en
关键词：
Breast Cancer Cancer Recurrence Cancer-Associated Fibroblasts Extracellular Matrix Genetically Engineered Mouse Model Immune Regulation Invadopodia Osteopontin Tumour Dormancy Tumour Microenvironment

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Breast cancer has one of the most promising prognoses yet remains the second deadliest cancer for one in eight Canadian women. Its morbidity is largely attributed to malignancies returning in patients, most of whom will eventually succumb and die from can
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