Remote Fiber Optic Biosensors: Optically Controlled Ligand Delivery

该项目将研究和开发一种通过受控光波脉冲将化学物质输送到人体内的系统。光控系统将解绑一些储存的化学物质，这些化学物质将扩散到第二根光纤上，光纤表面固定着单抗。由此产生的系统构成了一种远程、竞争性结合免疫分析，可以在光学控制下进行。这将为患者的治疗以及工业过程控制开辟新的可能性。远程光学试剂生成将成为生物研究的主要工具，能够精确控制、原位和远程将化学物质输送到微观区域。

This project will study and develop a system to deliver chemicals into the body by controlled lightwave pulses. The optically controlled system will unbind some stored chemical which will diffuse to a second optical fiber which contains monoclonal antibodies immobilized on its surface. The resulting system constitutes a remote, competitive binding immunoassay which can be performed under optical control. This will open up new possibilities in the treatment of patients as well as in industrial process control. Remote optical reagent generation will be a major tool in biological research, allowing precisely controlled ;itin situ;ro delivery of chemicals into microscopic areas.