U.S.-Korea Cooperative Research on Protein Interactions withGradient Surfaces

本提案要求资助犹他大学生物工程系Joseph D. Andrade博士与韩国化学技术研究所聚合物实验室Hai Bang Lee博士进行为期24个月的关于蛋白质与梯度表面相互作用的合作研究项目。合作者将制备和表征具有连续表面特性的样品，并研究一组蛋白质与这些表面的相互作用。美国队将采用溶液法，韩国队将采用真空干燥法。两个小组将研究表面特性，美国小组研究蛋白质吸附，韩国小组研究蛋白质处理前后表面的细胞粘附。这两个小组都将致力于数据解释和假设完善。蛋白质在固液界面的吸附在许多应用和行业中都很重要，包括分离、生物技术、医疗设备和诊断产品。合作者是长期从事聚合物研究的备受尊敬的科学家。目前的项目将使他们能够在互补的方法中结合他们的才能来研究研究问题。该项目与美韩合作科学项目的目标相关，该项目旨在通过科学信息、思想、技能和技术的交流以及在互利问题上的合作，提高美韩科学家和工程师之间的合作水平。

This proposal requests funds to permit Dr. Joseph D. Andrade, Department of Bioengineering, University of Utah, to pursue with Dr. Hai Bang Lee, Polymer Laboratory, Korea Research Institute of Chemical Technology, for a period of 24 months, a program of cooperative research on protein interactions with gradient surfaces. The collaborators will prepare and characterize samples which exhibit a continuous range of surface properties and study the interactions of a set of proteins with these surfaces. The U.S. team will prepare surfaces by a solution process, while the Korean team will use a "dry" vacuum process. Both groups will study surface characterization - the U.S. group studying protein adsorption, the Korean group studying cell adhesion on surfaces before and after protein treatment. Both group will work on data interpretation and hypothesis refinement. Protein adsorption at solid-liquid interfaces is important in many applications and industries, including separations, biotechnology, medical devices, and diagnostic products. The collaborators are highly respected scientists who have long been engaged in polymer research. The present project will allow them to combine their talents in complimentary approaches to a study of the research problem. This project is relevant to the objectives of the U.S.-Korea Cooperative Science Program which seeks to increase the level of cooperation between U.S. and Korean scientists and engineers through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit.