课题基金 / 基金详情

Antioxidant drugs protect b-cells from oxidative stress caused by hyperglycemia. Nonetheless small concentrations of reactive oxygen species support the insulin secretory response to glucose. b-cells contain superoxide dismutase but not catalase or glutat

抗氧化药物可保护 B 细胞免受高血糖引起的氧化应激。

批准号：

179946

负责人：

Kiraly Michael A

金额：

$10.93万

依托单位：

Pacific Northwest Research Institute (Seattle, WA)

依托单位国家：

加拿大

项目类别：

Fellowship Programs

财政年份：

2009

资助国家：

加拿大

项目状态：

已结题

起止时间：

2009-02-01 至 2012-02-01

来源：

https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=179946&lang=en

关键词：

Antioxidant Proteins Beta-Cell Diabetes Free Radicals/Reactive Oxygen Species Hyperglycemia In Vivo Islet Overexpression Oxidative Stress Regulation

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英文摘要

Clinical reports of elevated levels of oxidative stress markers in patients with type 2 diabetes mellitus (T2DM) are numerous. This is particularly relevant for the islet, which is among those tissues with the lowest levels of intrinsic antioxidant defens

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