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Targeting colorectal cancer-initiating cells and anti-EGFR therapeutic resistance by manipulating levels of the reactive aldehyde, 4-hydroxynonenal.

Targeting colorectal cancer-initiating cells and anti-EGFR therapeutic resistance by manipulating levels of the reactive aldehyde, 4-hydroxynonenal.
通过控制活性醛 4-羟基壬烯醛的水平，靶向结直肠癌起始细胞和抗 EGFR 治疗耐药性。
批准号：
302201
负责人：
O'Brien Catherine A
金额：
$21.86万
依托单位：
Ontario Cancer Institute (Toronto)
依托单位国家：
加拿大
项目类别：
Salary Programs
财政年份：
2013
资助国家：
加拿大
项目状态：
已结题
起止时间：
2013-12-01 至 2018-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=302201&lang=en
关键词：
4-Hydroxynonenal Aldehyde Dehydrogenase 1b1 Cancer-Initiating Cells Colorectal Cancer Egfr Glutathione S-Transferase Self-Renewal

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Colorectal cancer (CRC) is the 2nd leading cause of cancer mortality in Canada, with 9,200 deaths annually. We have previously shown that CRCs are initiated and maintained by a subset of colorectal cancer-initiating cells (CC-ICs). There is also increasin
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