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Colorectal cancer stem cell plasticity: A novel therapeutic target

Colorectal cancer stem cell plasticity: A novel therapeutic target
结直肠癌干细胞可塑性:一个新的治疗靶点
批准号:
334266
负责人:
O'Brien Catherine A
金额:
$88.93万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-09-01 至 2020-09-01

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中文摘要
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英文摘要
The purpose of my program is to understand how cancer cells are able to quickly adapt to an ever changing environment and how they acquire cancer stem cell activity. We have already identified factors driving adaptability, also known as plasticity, one of
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Inhibition of CBP/p300 bromodomain activity increases chemosensitivity of p53 mutant colorectal cancers through inhibiting p53 aggregation
  • 批准号:
    472399
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2022
  • 负责人:
    O'Brien Catherine A
  • 依托单位:
Molecular drivers of the drug tolerant persister state in patient-derived colorectal cancer models
  • 批准号:
    434963
  • 项目类别:
    Operating Grants
  • 资助金额:
    $69.94万
  • 财政年份:
    2020
  • 负责人:
    O'Brien Catherine A
  • 依托单位:
Canada Research Chair - Tier 2
  • 批准号:
    415401
  • 项目类别:
  • 资助金额:
    $43.71万
  • 财政年份:
    2019
  • 负责人:
    O'Brien Catherine A
  • 依托单位:
Targeting colorectal cancer-initiating cells and anti-EGFR therapeutic resistance by manipulating levels of the reactive aldehyde, 4-hydroxynonenal
  • 批准号:
    281581
  • 项目类别:
    Operating Grants
  • 资助金额:
    $45.58万
  • 财政年份:
    2013
  • 负责人:
    O'Brien Catherine A
  • 依托单位:
海外基金