Molecular drivers of the drug tolerant persister state in patient-derived colorectal cancer models
患者来源的结直肠癌模型中耐药持续状态的分子驱动因素
基本信息
- 批准号:434963
- 负责人:
- 金额:$ 69.94万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Operating Grants
- 财政年份:2020
- 资助国家:加拿大
- 起止时间:2020-10-01 至 2025-10-01
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Colorectal Cancer (CRC) is the 3rd highest cause of cancer-related deaths in North America. In total, 40% of CRC patients will develop metastatic disease and the majority of these patients will die of their disease. Thus despite being one of the best unde
结直肠癌(CRC)是北美癌症相关死亡的第三大原因。总的来说,40%的结直肠癌患者会发展为转移性疾病,其中大多数患者会死于疾病。因此,尽管是最好的球员之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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O'Brien Catherine A其他文献
O'Brien Catherine A的其他文献
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{{ truncateString('O'Brien Catherine A', 18)}}的其他基金
Inhibition of CBP/p300 bromodomain activity increases chemosensitivity of p53 mutant colorectal cancers through inhibiting p53 aggregation
抑制 CBP/p300 溴结构域活性通过抑制 p53 聚集增加 p53 突变结直肠癌的化疗敏感性
- 批准号:
472399 - 财政年份:2022
- 资助金额:
$ 69.94万 - 项目类别:
Operating Grants
Colorectal cancer stem cell plasticity: A novel therapeutic target
结直肠癌干细胞可塑性:一个新的治疗靶点
- 批准号:
334266 - 财政年份:2015
- 资助金额:
$ 69.94万 - 项目类别:
Operating Grants
Targeting colorectal cancer-initiating cells and anti-EGFR therapeutic resistance by manipulating levels of the reactive aldehyde, 4-hydroxynonenal.
通过控制活性醛 4-羟基壬烯醛的水平,靶向结直肠癌起始细胞和抗 EGFR 治疗耐药性。
- 批准号:
302201 - 财政年份:2013
- 资助金额:
$ 69.94万 - 项目类别:
Salary Programs
Targeting colorectal cancer-initiating cells and anti-EGFR therapeutic resistance by manipulating levels of the reactive aldehyde, 4-hydroxynonenal
通过控制活性醛 4-羟基壬烯醛的水平,靶向结直肠癌起始细胞和抗 EGFR 治疗耐药性
- 批准号:
281581 - 财政年份:2013
- 资助金额:
$ 69.94万 - 项目类别:
Operating Grants
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探索 HIKESHI 在胰腺癌肿瘤发展和热/化疗反应中的分子功能。
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Pre-clinical testing of low intensity ultrasound as novel strategy to prevent paclitaxel-induced hair follicle damage in a humanized mouse model of chemotherapy-induced alopecia
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Effects of Arginine Depletion Combined with Platinum-Taxane Chemotherapy in Aggressive Variant Prostate Cancers (AVPC)
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10715329 - 财政年份:2023
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10572695 - 财政年份:2023
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内皮 Smad3 作为避免化疗引起的心肌病的新靶点
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