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Molecular drivers of the drug tolerant persister state in patient-derived colorectal cancer models

Molecular drivers of the drug tolerant persister state in patient-derived colorectal cancer models
患者来源的结直肠癌模型中耐药持续状态的分子驱动因素
批准号:
434963
负责人:
O'Brien Catherine A
金额:
$69.94万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2020
资助国家:
加拿大
项目状态:
未结题
起止时间:
2020-10-01 至 2025-10-01

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中文摘要
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英文摘要
Colorectal Cancer (CRC) is the 3rd highest cause of cancer-related deaths in North America. In total, 40% of CRC patients will develop metastatic disease and the majority of these patients will die of their disease. Thus despite being one of the best unde
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Inhibition of CBP/p300 bromodomain activity increases chemosensitivity of p53 mutant colorectal cancers through inhibiting p53 aggregation
  • 批准号:
    472399
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2022
  • 负责人:
    O'Brien Catherine A
  • 依托单位:
Canada Research Chair - Tier 2
  • 批准号:
    415401
  • 项目类别:
  • 资助金额:
    $43.71万
  • 财政年份:
    2019
  • 负责人:
    O'Brien Catherine A
  • 依托单位:
Colorectal cancer stem cell plasticity: A novel therapeutic target
  • 批准号:
    334266
  • 项目类别:
    Operating Grants
  • 资助金额:
    $88.93万
  • 财政年份:
    2015
  • 负责人:
    O'Brien Catherine A
  • 依托单位:
Targeting colorectal cancer-initiating cells and anti-EGFR therapeutic resistance by manipulating levels of the reactive aldehyde, 4-hydroxynonenal.
  • 批准号:
    302201
  • 项目类别:
    Salary Programs
  • 资助金额:
    $21.86万
  • 财政年份:
    2013
  • 负责人:
    O'Brien Catherine A
  • 依托单位:
海外基金