Mechanisms of diabetes and aging in constitutively active, phosphorylation-resistant pRb knockin mice
Mechanisms of diabetes and aging in constitutively active, phosphorylation-resistant pRb knockin mice
批准号:
443790
负责人:
Zacksenhaus Eldad
金额:
$58.24万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2021
资助国家:
加拿大
项目状态:
未结题
起止时间:
2021-04-01 至 2026-04-01
中文摘要
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英文摘要
The tumor suppressor pRb is regulated by cyclin-dependent kinases (CDKs) that phosphorylate and inactivate it, leading to uncontrolled cell division. Conversely, inhibition of pRb phosphorylation suppresses cell division. Over the years, many studies with
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