Acquisition of an Electron Spin Resonance (ESR) Spectrometer

该提案要求提供资金，以取代一个主要的，高生产力的化学系的两个ESR光谱仪。研究者建议购买一台灵敏的、最先进的X品牌光谱仪，该光谱仪具有高速、多功能的数据处理能力，将有利于该仪器支持的研究项目，包括凝固途径的酶和蛋白质的自旋标记研究、体内ESR、酶和核酸中光诱导卡宾的化学和光亲和标记化学，血红素蛋白模型的结构表征和核糖体RNA的自旋标记研究。

This proposal requests funding to replace two ESR spectrometers in a major, highly productive Chemistry Department. The investigator proposes to purchase a sensitive, state-of-the-art x-brand spectrometer with high speed, versatile data handling capabilities that will benefit the research programs supported by this instrument encompass spin label studies of enzymes and proteins of the coagulation pathway, in-vivo ESR, the chemistry of photo-induced carbene and photo-affinity labeling chemistry in enzymes and nucleic acids, structural characterization of heme protein models and spin label studies of ribosomal RNA's.