The effect of genomic variants on Indigenous health

基因组变异对土著健康的影响

• 批准号: LP160100594
• 负责人: Dr Subashchandran Sankarasubramanian
• 金额: $ 12.39万
• 依托单位: University of the Sunshine Coast
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-08-03 至 2022-08-02
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP160100594
• 关键词: effect; genomic; variants; Indigenous; health

The effect of genomic variants on Indigenous health. This project aims to examine the genetic variants introduced by Europeans (and other groups) into the genomes of the Aboriginal Australian population. The rate of metabolic diseases such as diabetes and hypertension is very high in Australia’s Indigenous populations. While an energy-rich Western diet has been suggested as the major cause, the contribution of genomic variants (mutations) remains unclear. Anticipated outcomes are better understandings of both the benign and deleterious variants introduced into Aboriginal Australian populations and how these contribute to disease susceptibility.

基因组变异对土著健康的影响。该项目旨在研究欧洲人(和其他群体)引入澳大利亚土著人口基因组的遗传变异。在澳大利亚的土著居民中，糖尿病和高血压等代谢性疾病的发病率非常高。虽然能量丰富的西方饮食被认为是主要原因，但基因组变异(突变)的贡献仍不清楚。预期的结果是更好地了解引入澳大利亚土著人口的良性和有害变异，以及这些变异如何导致疾病易感性。