Development of Novel Polar MAO B Inhibitors for the Treatment of Epithelial Barrier Diseases

开发用于治疗上皮屏障疾病的新型极性 MAO B 抑制剂

• 批准号: 308166
• 负责人: Putnins Edward E
• 金额: $ 11.66万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-02-01 至 2015-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=308166&lang=en
• 关键词: Blood-Brain Barrier; Epithelial Barrier Integrity; Gastrointestinal Tract Infections; Inflammation; Irritable Bowel Syndromes; Monoamine Oxidase; Monoamine Oxidase B Inhibitors; Periodontal Disease; Polar Mao B Inhibitors; Tight Junctions

Loss of epithelial barrier integrity is common to many oral and gastrointestinal diseases including ulcerative colitis, periodontitis, and diarrheal diseases. Putnins et al. have demonstrated that monoamine oxidase (MAO) B, a pro-oxidative enzyme, is incr

上皮屏障完整性丧失是许多口腔和胃肠疾病的常见症状，包括溃疡性结肠炎、牙周炎和腹泻疾病。Putnins等人。已证明，单胺氧化酶(MAO)B是一种促氧化酶，它是一种