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Development of Novel Polar MAO B Inhibitors for the Treatment of Epithelial Barrier Diseases

Development of Novel Polar MAO B Inhibitors for the Treatment of Epithelial Barrier Diseases
开发用于治疗上皮屏障疾病的新型极性 MAO B 抑制剂
批准号：
308166
负责人：
Putnins Edward E
金额：
$11.66万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2014
资助国家：
加拿大
项目状态：
已结题
起止时间：
2014-02-01 至 2015-02-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=308166&lang=en
关键词：
Blood-Brain Barrier Epithelial Barrier Integrity Gastrointestinal Tract Infections Inflammation Irritable Bowel Syndromes Monoamine Oxidase Monoamine Oxidase B Inhibitors Periodontal Disease Polar Mao B Inhibitors Tight Junctions

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英文摘要
Loss of epithelial barrier integrity is common to many oral and gastrointestinal diseases including ulcerative colitis, periodontitis, and diarrheal diseases. Putnins et al. have demonstrated that monoamine oxidase (MAO) B, a pro-oxidative enzyme, is incr
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Regulation of Periodontal Disease Pathogenesis by the Effects of Novel Monoamine Oxidase B Inhibitors
  • 批准号：
    473042
  • 项目类别：
    Operating Grants
  • 资助金额：
    $7.29万
  • 财政年份：
    2022
  • 负责人：
    Putnins Edward E
  • 依托单位：
    University of British Columbia
Regulation of Periodontal Disease Pathogenesis by the Effects of Novel Monoamine Oxidase B Inhibitors
  • 批准号：
    456415
  • 项目类别：
    Operating Grants
  • 资助金额：
    $7.29万
  • 财政年份：
    2021
  • 负责人：
    Putnins Edward E
  • 依托单位：
    University of British Columbia
Protection and Regulation of Oral and Gastrointestinal Mucosal Epithelial Barriers by MAO B Inhibitors and Their Novel Polar Derivatives
  • 批准号：
    253591
  • 项目类别：
    Operating Grants
  • 资助金额：
    $47.55万
  • 财政年份：
    2012
  • 负责人：
    Putnins Edward E
  • 依托单位：
    University of British Columbia
Protection and Regulation of Oral and Gastrointestinal Mucosal Epithelial Barriers by MAO B Inhibitors and Their Novel Polar Derivatives
  • 批准号：
    250225
  • 项目类别：
    Operating Grants
  • 资助金额：
    $7.29万
  • 财政年份：
    2011
  • 负责人：
    Putnins Edward E
  • 依托单位：
    University of British Columbia
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