Micromechanical Regulation of Sperm Motility in Cervical Mucus & Other Biopolymers

宫颈粘液中精子活力的微机械调节

• 批准号: 8616134
• 负责人: David Katz
• 金额: $ 13.46万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-06-15 至 1990-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8616134&HistoricalAwards=false
• 关键词: Micromechanical; Regulation; Sperm; Motility; Cervical

This project applies both theoretical and experimental fluid mechanics and rheology to a fundamental problem in the biology of sperm motion and eventual fertility. The problem involves the interaction of swimming sperm with biopolymeric fluid secretions found within the female reproductive tract, primarily cervical mucus. Spermatozoa must successfully migrate through such biopolymeric gels in order to reach the egg. At present, relatively little is known about the fundamental mechanics of the sperm-mucus interaction: i.e. of the material properties of mucus which sperm experience; and of the hydrodynamics of sperm swimming in such obviously non-Newtonian fluids. The proposed project, in order to address an important biomedical question, will undertake studies that address these two questions.

本项目采用理论和实验流体 力学和流变学的一个基本问题， 精子运动和最终的生育能力。 这个问题涉及到 游动精子与生物聚合物液体分泌物的相互作用 在女性生殖道内发现，主要是宫颈 粘液。 精子必须成功地通过这种 生物聚合物凝胶才能到达卵子。 目前， 相对而言，人们对这一过程的基本机制知之甚少。 精子-粘液相互作用：即粘液的物质特性 精子所经历的，以及精子的流体动力学 在如此明显的非牛顿流体中游泳。 拟议 为了解决一个重要的生物医学问题， 将针对这两个问题进行研究。