Development of Cortico Cortical Connectivity in Monkey Association Cortex

本实验旨在研究恒河猴大脑前额叶皮层连接的发展。了解额叶皮层（皮质）两个叶之间联系的最新进展。成熟猴子的皮质连接（Cortical connections）使其成为研究支配它们发育的规则和机制的模型系统。施瓦兹博士将进行实验，提供两个方面发育的详细信息：(1)皮质长入的速度和模式。(2)胼胝体轴突产生的突触接触的产生、目标和增殖速度，以及这些事件与柱状组织的关系。这些研究将使用神经解剖示踪剂HRP和氚化氨基酸在光镜和电子显微镜水平上检查胎儿和新生猴。这些实验结果将为研究发育中的灵长类动物大脑皮层轴突生长和连接形成提供重要的新信息。的 cortico。灵长类动物前额皮质的皮质连接是高度发达的。在人类和猴子额叶损伤后发现的行为障碍模式的相似性表明，猴子前额叶皮层可能为理解人类认知功能的结构和功能提供了一个重要的模型。

The experiments in this proposal are designed to examine the development of connectivity in the prefrontal cortex of the rhesus monkey brain. Recent advances in understanding the connections between the two lobes of the frontal cortex (cortico.cortical connec tions) in mature monkeys make this a model system for examining the rules and mechanisms which govern their development. Dr. Schwartz will conduct experiments to provide detailed information on two aspects of development: (1) the tempo and pattern of ingrowth of cortico.cortical axons in the prefrontal cortex, and (2) the generation, targets and tempo of proliferation of synaptic contacts arising from callosal axons and the relationship of these events to columnar organization. These studies will examine fetal and neonatal monkeys using the neuroanatomical tracers HRP and tritiated amino acids at the light and electron microscope level. The results of these experiments will provide important new information on aspects of axonal growth and connectivity formation in the cerebral cortex of developing primates. The cortico.cortical connections in the prefrontal cortex of primates are highly developed. Similarities in the pattern of behavioral impairments found following damage to the frontal lobes in humans and monkeys suggest that the monkey prefrontal cortex may provide an important model for understanding the structure and function of cognitive functions on humans.