First-in-Class Small-molecule Inhibitors Selectively Targeting the DNA-binding Domain of Human Androgen Receptor and Its Splice Variants for the Treatment of Resistant Prostate Cancer
选择性靶向人雄激素受体及其剪接变体的 DNA 结合域的一流小分子抑制剂,用于治疗耐药性前列腺癌
基本信息
- 批准号:308059
- 负责人:
- 金额:$ 10.93万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Operating Grants
- 财政年份:2014
- 资助国家:加拿大
- 起止时间:2014-02-01 至 2015-02-01
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Prostate cancer is the most commonly diagnosed non-skin cancer in Canadian men and one of the leading causes of cancer-related death. If diagnosed early, when still confined to the prostate, it is frequently curable by surgery or radiotherapy. Treatment f
前列腺癌是加拿大男性中最常见的非皮肤癌,也是癌症相关死亡的主要原因之一。如果早期诊断,当仍然局限于前列腺时,它通常可以通过手术或放射治疗治愈。治疗f
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Cherkasov Artem其他文献
Cherkasov Artem的其他文献
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{{ truncateString('Cherkasov Artem', 18)}}的其他基金
COVID-19 Variant Network - Computer-aided discovery of synergistic drug combinations with Remdevisir for COVID-19 through mechanism-based drug repurposing and combinatorial organoid screening.
COVID-19 Variant Network - 通过基于机制的药物再利用和组合类器官筛选,计算机辅助发现与 Remdevisir 治疗 COVID-19 的协同药物组合。
- 批准号:
443064 - 财政年份:2021
- 资助金额:
$ 10.93万 - 项目类别:
Operating Grants
COVID-19 Variant Supplement - Computer-aided discovery of synergistic drug combinations with Remdevisir for COVID-19 through mechanism-based drug repurposing and combinatorial organoid screening.
COVID-19 Variant Supplement - 通过基于机制的药物再利用和组合类器官筛选,计算机辅助发现与 Remdevisir 治疗 COVID-19 的协同药物组合。
- 批准号:
443137 - 财政年份:2021
- 资助金额:
$ 10.93万 - 项目类别:
Operating Grants
Computer-aided discovery of synergistic drug combinations with Remdevisir for COVID-19 through mechanism-based drug repurposing and combinatorial organoid screening.
通过基于机制的药物再利用和组合类器官筛选,计算机辅助发现与 Remdevisir 治疗 COVID-19 的协同药物组合。
- 批准号:
429444 - 财政年份:2020
- 资助金额:
$ 10.93万 - 项目类别:
Operating Grants
Sex as a Biological Variable Supplement - Augmented Discovery of Potential Inhibitors of SARS-CoV-2 3CL Protease
性别作为生物变量补充剂 - 增强 SARS-CoV-2 3CL 蛋白酶潜在抑制剂的发现
- 批准号:
424703 - 财政年份:2020
- 资助金额:
$ 10.93万 - 项目类别:
Operating Grants
Augmented Discovery of Potential Inhibitors of SARS-CoV-2 3CL Protease
SARS-CoV-2 3CL 蛋白酶潜在抑制剂的增强发现
- 批准号:
422705 - 财政年份:2020
- 资助金额:
$ 10.93万 - 项目类别:
Operating Grants
Design and evaluation of small molecules that target the dimerization interface of full-length and splice-variant forms of the androgen receptor as a potential treatment for advanced prostate cancer
设计和评估以雄激素受体全长和剪接变体形式的二聚化界面为目标的小分子作为晚期前列腺癌的潜在治疗方法
- 批准号:
370554 - 财政年份:2017
- 资助金额:
$ 10.93万 - 项目类别:
Operating Grants
Next generation anti-androgens for the treatment of castration-resistant prostate cancers
用于治疗去势抵抗性前列腺癌的下一代抗雄激素
- 批准号:
251984 - 财政年份:2012
- 资助金额:
$ 10.93万 - 项目类别:
Operating Grants
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检测受废水排放和农业径流影响的地表水中的抗雌激素和抗雄激素
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蜗牛测定作为啮齿动物赫什伯格测定的替代方法来检测雄激素和抗雄激素
- 批准号:
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基于细胞的抗雄激素高通量筛选
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环境抗雄激素和 AR 自动调节
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6877028 - 财政年份:2002
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$ 10.93万 - 项目类别:
ENVIRONMENTAL ANTI-ANDROGENS AND AR AUTOREGULATION
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- 批准号:
6382115 - 财政年份:2001
- 资助金额:
$ 10.93万 - 项目类别:














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