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First-in-Class Small-molecule Inhibitors Selectively Targeting the DNA-binding Domain of Human Androgen Receptor and Its Splice Variants for the Treatment of Resistant Prostate Cancer

First-in-Class Small-molecule Inhibitors Selectively Targeting the DNA-binding Domain of Human Androgen Receptor and Its Splice Variants for the Treatment of Resistant Prostate Cancer
选择性靶向人雄激素受体及其剪接变体的 DNA 结合域的一流小分子抑制剂，用于治疗耐药性前列腺癌
批准号：
308059
负责人：
Cherkasov Artem
金额：
$10.93万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2014
资助国家：
加拿大
项目状态：
已结题
起止时间：
2014-02-01 至 2015-02-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=308059&lang=en
关键词：
Androgen Receptor (Ar) Anti-Androgens Ar Splice Variants Computer-Aided Drug Design Drug Resistance Prostate Cancer Small Molecule Inhibitors

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Prostate cancer is the most commonly diagnosed non-skin cancer in Canadian men and one of the leading causes of cancer-related death. If diagnosed early, when still confined to the prostate, it is frequently curable by surgery or radiotherapy. Treatment f
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