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Design and evaluation of small molecules that target the dimerization interface of full-length and splice-variant forms of the androgen receptor as a potential treatment for advanced prostate cancer

Design and evaluation of small molecules that target the dimerization interface of full-length and splice-variant forms of the androgen receptor as a potential treatment for advanced prostate cancer
设计和评估以雄激素受体全长和剪接变体形式的二聚化界面为目标的小分子作为晚期前列腺癌的潜在治疗方法
批准号：
370554
负责人：
Cherkasov Artem
金额：
$33.44万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-09-01 至 2020-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=370554&lang=en
关键词：
Androgen Receptor Drug-Design Prostate Cancer Small Molecule Inhibitors Transciption Factor Dimerization

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英文摘要
Prostate cancer continues to be a leading cause of death for men in North America The main factor that drives the transformation that changes normal prostate tissue into cancerous lesions is the androgen receptor (AR), a molecular signalling protein, whic
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