Toxicity Testing in Wastewater Treatment Plants: Application of a Short-Term Assay Based on Induction of the Lac Operon in E. Coli
废水处理厂的毒性测试:基于大肠杆菌紫胶操纵子诱导的短期测定的应用
基本信息
- 批准号:8619073
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing grant
- 财政年份:1987
- 资助国家:美国
- 起止时间:1987-08-01 至 1990-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
As a result of increasing demand for chemicals, the industrialized world faces the problem of release of these often toxic substances in the environment. There is therefore a need to assess the impacts of these toxicants on the environment. The major objective of this research project is to develop an enzymatic toxicity testing method. The enzymatic activity of betagalactosidase in E. Coli will be used as the toxicity testing mechanism. Various toxicants including inorganic and organic substances will be used for study. The toxicity assay will be further studied to better understand the effects of toxicants on enzyme induction by a gratuitous inducer such as isopropylthiogalactoside (IPTG). The development of a miniaturized test and the use of immobilized E. Coli cells will also be considered. Various means to: sensitize E. Coli cells to environmental toxicants will be explored. The principal investigator is highly qualified to perform this research. A two year continuing grant is recommended. This award is for $90,198 for the first year.
由于对化学品的需求不断增加,工业化国家 面临着这些有毒物质释放的问题, 环境 因此,有必要评估这些措施的影响。 对环境有毒物质。 本研究的主要目的是 本项目旨在开发一种酶毒性检测方法。 的 β-半乳糖苷酶在E.大肠杆菌将被用作 毒性测试机制 各种有毒物质,包括无机和 有机物质将用于研究。 毒性试验将 进一步研究,以更好地了解毒物对酶的影响 通过无偿诱导剂如异丙基硫代半乳糖苷诱导 (IPTG)。 小型化测试的开发和使用 固定化E.还将考虑大肠杆菌细胞。 采取各种手段: 致敏E.将探讨大肠杆菌细胞对环境毒物的反应。 主要研究者非常有资格进行这项研究。 建议提供两年连续补助金。 此奖项为$90,198 第一年
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gabriel Bitton其他文献
Inhibition of hydrogen sulfide generation from disposed gypsum drywall using chemical inhibitors
- DOI:
10.1016/j.jhazmat.2011.04.063 - 发表时间:
2011-07-15 - 期刊:
- 影响因子:
- 作者:
Qiyong Xu;Timothy Townsend;Gabriel Bitton - 通讯作者:
Gabriel Bitton
The Barmer study: impact of standardized warming of the injection site to enhance insulin absorption and reduce prandial insulin requirements and hypoglycemia in obese patients with diabetes mellitus
Barmer 研究:注射部位标准化加温对肥胖糖尿病患者增强胰岛素吸收、减少餐时胰岛素需求和低血糖的影响
- DOI:
10.1185/03007995.2014.880049 - 发表时间:
2014 - 期刊:
- 影响因子:2.3
- 作者:
A. Pfützner;N. Hermanns;K. Funke;Thomas Forst;T. Behnke;Gabriel Bitton;Ron Nagar;Itamar Raz;T. Haak - 通讯作者:
T. Haak
Evaluation of membrane adsorption-epifluorescence microscopy for the enumeration of bacteria in coastal surface films
- DOI:
10.1007/bf02341431 - 发表时间:
1981-12-01 - 期刊:
- 影响因子:4.000
- 作者:
Linda M. Sewell;Gabriel Bitton;James S. Bays - 通讯作者:
James S. Bays
Standardized modulation of the injection site allows for insulin dose reduction without deterioration of metabolic control
注射部位的标准化调节可以减少胰岛素剂量,而不会恶化代谢控制
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:2.3
- 作者:
A. Pfützner;S. Dissel;C. Forkel;M. Grenningloh;Gabriel Bitton;Ron Nagar;Thomas Forst - 通讯作者:
Thomas Forst
Toxicity testing of sediment elutriates based on inhibition of alpha-glucosidase biosynthesis inBacillus licheniformis
- DOI:
10.1007/bf01146163 - 发表时间:
1993-05-01 - 期刊:
- 影响因子:2.200
- 作者:
Marjorie Campbell;Gabriel Bitton;Ben Koopman - 通讯作者:
Ben Koopman
Gabriel Bitton的其他文献
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{{ truncateString('Gabriel Bitton', 18)}}的其他基金
US-Morocco Cooperative Research: Environmental Contamination and Toxicity Caused by Heavy Metals Released from a Closed Mine in Marrakech, Morocco
美国-摩洛哥合作研究:摩洛哥马拉喀什关闭矿山释放重金属造成的环境污染和毒性
- 批准号:
0096819 - 财政年份:2001
- 资助金额:
-- - 项目类别:
Standard Grant
Assessment of the Toxicity and Endocrine Disruption Potential of Municipal, Construction and Demolition, and Industrial Solid Wastes
市政、建筑和拆除以及工业固体废物的毒性和内分泌干扰潜力评估
- 批准号:
9906060 - 财政年份:1999
- 资助金额:
-- - 项目类别:
Continuing grant
Use of Microbial Assays to Distinguish Between Heavy Metal and Organic Chemical Toxicity
使用微生物分析来区分重金属和有机化学毒性
- 批准号:
9117267 - 财政年份:1992
- 资助金额:
-- - 项目类别:
Continuing grant
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- 批准号:
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