Assessment of the Toxicity and Endocrine Disruption Potential of Municipal, Construction and Demolition, and Industrial Solid Wastes

市政、建筑和拆除以及工业固体废物的毒性和内分泌干扰潜力评估

• 批准号: 9906060
• 负责人: Gabriel Bitton
• 金额: --
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2003-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9906060&HistoricalAwards=false
• 关键词: Assessment; Toxicity; Endocrine; Disruption; Potential

9906060 Bitton This is an award to support research on toxicology of leachates emerging from landfills containing solid wastes originating from landfills that contain municipal and industrial construction and demolition debris. The leachates from three existing landfills will be studied to determine their acute toxicity applying procedures developed in research conducted under NSF Grant No. BES 91-17267 in which procedures were developed to use microbial assays to distinguish between heavy metal and organic chemical toxicity. In this new project, the baseline toxicity of leachates from existing solid waste landfills in Alachua, Citrus and Levy Counties in Florida will be studied to determine their baseline toxicities, the extent to which these are attributable to their content of heavy metals and to determine their potential for endocrine disruption. Leachates will also be produced in laboratory columns simulating exposure of solid wastes to rainfall and in batch procedures using buffers, deionized water and solvents as eluants. These leachates will be passed through soil columns to determine the toxicity attenuation potential achieved by passage through soil. A recombinant yeast will be used to detect environmental estrogens in mixed solid waste and vitellogen produced by fathead minnows will be used as a biomarker for assessment of endocrine disruption. Solid wastes from construction and demolition activities are generally placed on sites and in landfills that are not lined or otherwise designed or constructed to prevent or restrain leachate from contaminating soil and groundwater. Results of this research are likely to provide knowledge that can be used to determine the appropriate placement and engineering design of landfills to avoid pollution of soil, surface and groundwater by landfill leachates. The work is also expected to validate short-term assays that can be used to rapidly detect the potential a solid waste has for toxicity, endocrine disruption and other deleterious environmental effects on environmental resources.***

9906060 Bitton这是一个奖项，以支持从垃圾填埋场产生的沥滤液的毒理学研究，这些沥滤液含有来自垃圾填埋场的固体废物，这些垃圾填埋场含有市政和工业建筑和拆除碎片。 将对三个现有垃圾填埋场的沥滤液进行研究，以确定其急性毒性，采用在NSF批准号BES 91-17267下进行的研究中开发的程序，其中开发的程序使用微生物测定来区分重金属和有机化学品毒性。 在这一新项目中，将研究佛罗里达阿拉楚阿、柑橘和莱维县现有固体废物填埋场沥出物的基线毒性，以确定其基线毒性，这些毒性在多大程度上归因于其重金属含量，并确定其扰乱内分泌的潜力。 还将在模拟固体废物暴露于降雨的实验室柱中以及在使用缓冲液、去离子水和溶剂作为洗脱剂的分批程序中产生沥滤液。 这些沥滤液将通过土壤柱，以确定通过土壤达到的毒性衰减潜力。 一种重组酵母将被用于检测混合固体废物中的环境雌激素，黑头呆鱼产生的卵黄蛋白将被用作评估内分泌干扰的生物标志物。建筑和拆卸活动产生的固体废物通常被放置在没有衬里或以其他方式设计或建造以防止或限制渗滤液污染土壤和地下水的场地和填埋场。 这项研究的结果可能提供的知识，可用于确定适当的位置和工程设计的垃圾填埋场，以避免污染土壤，地表水和地下水的垃圾填埋场渗滤液。 预计这项工作还将验证可用于快速检测固体废物对环境资源的毒性、内分泌干扰和其他有害环境影响的可能性的短期分析。