Theory of Relaxation Times Associated with Contrast Agents in Magnetic Resonance Imaging

磁共振成像中与造影剂相关的弛豫时间理论

• 批准号: 8619660
• 负责人: Tara Das
• 金额: $ 10.8万
• 依托单位: SUNY at Albany
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-04-15 至 1991-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8619660&HistoricalAwards=false
• 关键词: Theory; Relaxation; Times; Associated; Contrast

This project is aimed at a first-principles understanding of the influence of paramagnetic ion systems on the relaxation times of protons of water molecules and therefore on the contrast-noise ratio for magnetic resonance imaging (MRI). The magnetic moment distributions between the paramagnetic ion and its ligands will be studied using both ab initio and approximate theoretical techniques, and the effects of these distributions on the contact and dipolar hyperfine interactions will be assessed. Systems to be studied include transition-metal and rare-earth ions, and such ions linked to protein molecules. These studies are expected to contribute to a more detailed understanding and interpretation of the biomedically important MRI technique. The images produced by MRI can be sharpened (i.e., heighten the contrast and reduce the noise) by chemical compounds containing certain metal atoms, but these may also have toxic side effects. This project is aimed at a fundamental understanding of how these compounds work to sharpen the image; appropriate non-toxic substances for administration to patients can then be devised.

该项目旨在了解第一原理， 顺磁离子体系对弛豫时间的影响 水分子的质子， 磁共振成像（MRI）的比率。 磁矩 顺磁性离子与其配体之间的分布将 使用从头算和近似理论 技术，以及这些分布对接触的影响 并评估偶极超精细相互作用。 系统来 包括过渡金属和稀土离子等 连接蛋白质分子的离子。 预计这些研究将有助于更详细地 理解和解释生物医学上重要的 MRI技术。 MRI产生的图像可以被锐化 (i.e.,提高对比度和降低噪声 含有某些金属原子的化合物，但这些化合物也可能具有 毒副作用 该项目旨在从根本上 了解这些化合物如何发挥作用以增强 成像;适当无毒物质， 患者可以进行设计。