Evaluation of the Effectiveness of Chemotherapy in Rheumatoid Arthrits by the Malignancy Index Devided from the Relaxation Times of Nuclear Magnetic Resonance and Production of the Sofowere to Get the Malignancy Index.

通过核磁共振弛豫时间和 Sofowere 产生的恶性指数评估类风湿性关节炎化疗的有效性。

• 批准号: 05555115
• 负责人: YAMASAKI Masaki
• 金额: $ 3.58万
• 依托单位: Yatushiro National College of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05555115/
• 关键词: Synovial Fluid; Rheumatoid Arthritis; Osteoarthritis; Chemotherapy; Malignancy Index; NMR; Relaxation Time; Software; Malignancy Index

Application of the nuclear magnetic resonance (NMR) method has been attemted in the medical field as a new diagnostic technique.In this research, we have systematically studied the NMR relaxatin times (T_1 and T_2) of water protons in the synovial fluid of human Rheumatoid Arthritis and Osteoarthritis.Using the values of the malignancy index derived from the relaxation times (T_1 and T_2) of these disease, it has been possible to discriminate clearly between Rheumatoid Arthritis and Osteoarthritis, and also to evaluate the effectiveness of chemotherapy in these arthritis disease.The malignancy index, furthermore, was compatible with the histological evaluation of the effectiveness of chemotherapy in these disease.

核磁共振（NMR）方法作为一种新的诊断技术已被尝试在医学领域中应用。在本研究中，我们系统地研究了人类类风湿性关节炎和骨关节炎滑液中水质子的NMR弛豫时间（T_1和T_2）。利用这些弛豫时间（T_1和T_2）推导出的恶性指数值 疾病，已经可以清楚地区分类风湿性关节炎和骨关节炎，并且还可以评估化疗在这些关节炎疾病中的有效性。此外，恶性指数与化疗在这些疾病中的有效性的组织学评估相一致。

项目成果

Yamasaki,M.: "Inspection of Synovial Fluid in Rheumatoid Arthritis and Osteoarthritis by Nuclear Magnetic Resonance." Jpn.J.Orthop.

Yamasaki,M.：“通过核磁共振检查类风湿性关节炎和骨关节炎的滑液。”

Yamasaki, M.: "Inspection of Synovial Fluid in Rheumatoid Arthritis and Osteoarthritis by Nuclear Magnetic Resonance" Jpn. J. Orthop.

Yamasaki, M.：“通过核磁共振检查类风湿关节炎和骨关节炎的滑液”Jpn。