Midwest Center for Mass Spectrometry: Instrument and Method Development

这个项目属于仪器开发领域。具有非凡灵敏度和碰撞诱导解离能力的新一代四扇形质谱仪的开发将与傅立叶变换质谱（FTMS）项目并行进行。在前一种情况下，中西部质谱中心的工作将继续进行，并将额外的重点放在新仪器的设计、建造、评估和应用上，以解决化学和生物学中的重要问题。研究将在三个重要方面进行，包括：用于生物分子结构解析的快速原子轰击和二次离子质谱，生命科学难题的合作研究，以及在观察碰撞产物时需要高灵敏度和/或更好的质量分辨率的化学研究。此外，将继续进行超痕量分析和离子化学研究。FTMS的项目将侧重于模型开发、工具开发和仪器开发，以解决重要的化学问题。持续的研究将包括基于激光的FTMS方法和FTMS串联质谱方法的进一步研究。因此，质谱学的两个中心重要领域将包含在本项目中。

This project is in the area of instrument development. A two- pronged effort in development of a new generation quadruple sector mass spectrometer with extraordinary sensitivity and the capability for collision iduced dissociation will be conducted in parallel with a project involving Fourier transform mass spectrometry (FTMS). In the former case the efforts of the Midwest Center for Mass Spectrometry will be continued with the additional focus of the design, construction, evaluation, and application of the new instrument to important problems in chemistry and biology. Research will be conducted on three important fronts including: fast atom bombardment and secondary ion mass spectrometry for structural elucidation of biomolecules, collaborative research on difficult problems in the life sciences, and chemical studies that require high sensity and/or better mass resolution in the observation of collision products. In addition, ultratrace analysis and ion chemistry studies will be continued. The program in FTMS will focus on model development, tool development, and instrumentation development directed toward solving significant chemical problems. Continuing research will include laser-based methods for FTMS and further investigation of tandem mass spectrometry approaches by FTMS. Thus, two centrally important areas in mass spectrometry will be encompassed in this project.