Midwest Center for Mass Spectrometry: Instrument and Method Development

这个项目是在仪器开发领域。在开发具有非凡灵敏度和碰撞诱导解离能力的新一代四扇形质谱计方面，将双管齐下，同时开展一个涉及傅立叶变换质谱学(FTMS)的项目。在前一种情况下，中西部质谱学中心的工作将继续进行，并将重点放在新仪器的设计、建造、评估和应用于重要的化学和生物问题上。将在三个重要方面进行研究，包括：用于生物分子结构鉴定的快速原子轰击和二次离子质谱学，生命科学中的疑难问题的合作研究，以及在观察碰撞产物时需要高灵敏度和/或更高质量分辨率的化学研究。此外，还将继续进行超痕量分析和离子化学研究。FTMS中的计划将专注于模型开发、工具开发和仪器开发，旨在解决重要的化学问题。继续的研究将包括FTMS的基于激光的方法和FTMS对串联质谱学方法的进一步研究。因此，该项目将涵盖质谱学中的两个核心重要领域。

This project is in the area of instrument development. A two- pronged effort in development of a new generation quadruple sector mass spectrometer with extraordinary sensitivity and the capability for collision iduced dissociation will be conducted in parallel with a project involving Fourier transform mass spectrometry (FTMS). In the former case the efforts of the Midwest Center for Mass Spectrometry will be continued with the additional focus of the design, construction, evaluation, and application of the new instrument to important problems in chemistry and biology. Research will be conducted on three important fronts including: fast atom bombardment and secondary ion mass spectrometry for structural elucidation of biomolecules, collaborative research on difficult problems in the life sciences, and chemical studies that require high sensity and/or better mass resolution in the observation of collision products. In addition, ultratrace analysis and ion chemistry studies will be continued. The program in FTMS will focus on model development, tool development, and instrumentation development directed toward solving significant chemical problems. Continuing research will include laser-based methods for FTMS and further investigation of tandem mass spectrometry approaches by FTMS. Thus, two centrally important areas in mass spectrometry will be encompassed in this project.