Midwest Center for Mass Spectrometry: Instrument and Method Development

该项目属于仪器开发领域。 两个- 全力发展新一代四合一 灵敏度极高的扇形质谱仪， 碰撞诱导解离的能力将在 与涉及傅里叶变换质量的项目平行 光谱法（FTMS）。 在前一种情况下， 中西部质谱中心将继续与 设计、施工、评估和 新仪器在重大问题上的应用 化学和生物学。 研究将在三个 重要前沿包括：快速原子轰击和次级 用于生物分子结构解析的离子质谱法， 生活难题合作研究 科学和化学研究，需要高灵敏度和/或 在观测碰撞产物时有更好的质量分辨率。 此外，超痕量分析和离子化学研究将 请继续。 FTMS中的程序将侧重于模型 开发、工具开发和仪器开发 致力于解决重大的化学问题。 持续的研究将包括基于激光的FTMS方法， 进一步研究串联质谱法， FTMS。 因此，质谱分析中的两个重要领域 都将包含在这个项目中。

This project is in the area of instrument development. A two- pronged effort in development of a new generation quadruple sector mass spectrometer with extraordinary sensitivity and the capability for collision iduced dissociation will be conducted in parallel with a project involving Fourier transform mass spectrometry (FTMS). In the former case the efforts of the Midwest Center for Mass Spectrometry will be continued with the additional focus of the design, construction, evaluation, and application of the new instrument to important problems in chemistry and biology. Research will be conducted on three important fronts including: fast atom bombardment and secondary ion mass spectrometry for structural elucidation of biomolecules, collaborative research on difficult problems in the life sciences, and chemical studies that require high sensity and/or better mass resolution in the observation of collision products. In addition, ultratrace analysis and ion chemistry studies will be continued. The program in FTMS will focus on model development, tool development, and instrumentation development directed toward solving significant chemical problems. Continuing research will include laser-based methods for FTMS and further investigation of tandem mass spectrometry approaches by FTMS. Thus, two centrally important areas in mass spectrometry will be encompassed in this project.