Ion Exchange of Amino Acids Peptides and Proteins - Intrinsic Kinetics Theromodynamic Equilibria Transport and Interference Effects

氨基酸肽和蛋白质的离子交换 - 内在动力学热力学平衡传递和干扰效应

• 批准号: 8620221
• 负责人: Nien-Hwa Wang
• 金额: $ 19.48万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-01-15 至 1990-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8620221&HistoricalAwards=false
• 关键词: Ion; Exchange; Amino; Acids; Peptides

Commercially-successful production of useful biochemicals such as insulin, growth hormone, and interferon depends on the efficiency and effectiveness of the processes for purifying these substances. Considerable advances have been made in recent years on the molecular biology of these substances. Therefore the time is ripe for studying the molecular ion-exchange phenomena (kinetics, thermodynamics, etc.) that are relevant in the design of large-scale separation processes. This research outlines a systematic study of such phenomena and promises to be of potential value in advancing bioseparation technology.

如胰岛素、生长激素和干扰素等有用生化物质的商业成功生产取决于这些物质净化过程的效率和有效性。近年来，这些物质的分子生物学研究取得了相当大的进展。因此，研究与大规模分离过程设计相关的分子离子交换现象（动力学、热力学等）的时机已经成熟。本研究概述了这种现象的系统研究，并承诺在推进生物分离技术的潜在价值。