Presidential Young Investigator Award: Protein Expression in E. coli During Transitional Growth.

旁白：这个奖项支持一位总统青年调查员 (PYI)研究各种生化工程问题。 目前的工作重点是细胞过程，酶学， 为工厂设计制定分析和评估框架。 已经完成的工作包括一个演示， 生理功能（如信息传导） 通道特性与结构之间的权衡 （活动/监管机制组织）和工作点 （代谢物状态向量），以及 单活性和多活性酶-膜反应器系统。 未来的工作包括实验和理论研究， 潜在的分子和物理过程， 细胞的生长动力学、调节和能量学。 小说 生物反应器将被设计来研究物理，化学和 更好地理解反应堆的生物现象 操作 生物工艺设计，如开发框架工程 从而对关键的可操作过程的设计产生影响， （细胞的，分子的）可以被评估。 同时，蛋白质运输 现象将被调查，以确定如何改变 构象状态和自缔合程度的影响 进入/在多孔分离介质内的迁移性。

Narravtive: This award supports a Presidential Young Investigator (PYI) to study a variety of Biochemical Engineering problems. Current work focuses on cellular processes, enzymology, and developing analysis and evaluation frameworks for plant design. Work that has been completed includes a demonstration that physiological function (e.g. information transduction) linked pathway properties trade off with respect to structure (activity/regulatory mechanism organization) and operating point (metabolite state vector), and fundamental investigations with single and multiactivity enzyme-membrane reactor systems. Future work includes experimental and theoretical studies of underlying molecular and physical processes that play a role in growth kinetics, regulation, and energetics of cells. Novel bioreactors will be devised to study physical, chemical and biological phenomena for a better understanding of reactor operation. Bioprocess design, such as developing frame works whereby the impact on design of key, manipulable processes (cellular, molecular) can be assessed. Also, protein transport phenomena will be investigated to determine how alteration of conformational state and extent of self association influences mobility into/within porous separation media.