Structure and Dynamics of Transfer RNA

转移RNA的结构和动力学

• 批准号: 8706551
• 负责人: Stephen Harvey
• 金额: $ 23.9万
• 依托单位: University of Alabama at Birmingham
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1991-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8706551&HistoricalAwards=false
• 关键词: Structure; Dynamics; Transfer; RNA

From a structural standpoint, tRNA's are an important class of molecules. They were the first naturally occurring nucleic acids to be sequenced and to yield to crystallographic analysis, and they contain many features common to nucleic acid structure. Biologically, they stand at the center of the machinery for translating the genetic code into protein sequences and they interact with a large number of other macromolecules. A deeper understanding of the principles that determine tRNA structure, dynamics and interactions is an important goal. Dr. Harvey will continue the development of computer-based models for transfer RNA and the use of these models to examine a number of questions about tRNA structure, dynamics and interactions with other molecules.

从结构的角度来看，tRNA是一类重要的 分子。 它们是第一个自然产生的 待测序的核酸并产生 晶体学分析，它们包含许多特征， 与核酸结构相同。 从生物学角度来说， 在转译基因机器的中心， 编码成蛋白质序列， 其他大分子。 更深入地了解 确定tRNA结构、动力学和 互动是一个重要的目标。 哈维博士将继续开发基于计算机的 转移RNA的模型和使用这些模型 研究了一些关于tRNA结构，动力学 以及与其他分子的相互作用。